Towards translational therapies for multiple system atrophy
Identifieur interne : 000883 ( Main/Exploration ); précédent : 000882; suivant : 000884Towards translational therapies for multiple system atrophy
Auteurs : Daniela Kuzdas-Wood [Autriche] ; Nadia Stefanova [Autriche] ; Kurt A. Jellinger [Autriche] ; Klaus Seppi [Autriche] ; Michael G. Schlossmacher [Canada] ; Werner Poewe [Autriche] ; Gregor K. Wenning [Autriche]Source :
- Progress in Neurobiology [ 0301-0082 ] ; 2014.
Abstract
This review summarizes the progress made in MSA research during the past decade. Pre-motor features have gained relevance as early diagnostic markers. Animal models have been exploited to discover novel interventional targets. Candidate α-synuclein lowering therapies have been explored in preclinical models.
Url:
DOI: 10.1016/j.pneurobio.2014.02.007
PubMed: 24598411
PubMed Central: 4068324
Affiliations:
- Autriche, Canada
- Tyrol (Land), Vienne (Autriche)
- Innsbruck, Vienne (Autriche)
- Université de médecine d'Innsbruck
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Le document en format XML
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Jellinger</name><affiliation wicri:level="3"><nlm:aff id="aff0010">Institute of Clinical Neurobiology, Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Clinical Neurobiology, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Neurology, Innsbruck Medical University, Anichstraße 35, Innsbruck 6020, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Innsbruck Medical University, Anichstraße 35, Innsbruck 6020</wicri:regionArea><wicri:noRegion>Innsbruck 6020</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Divisions of Neuroscience and Neurology, The Ottawa Hospital Research Institute, University of Ottawa, 451 Smyth Road, RGH #1412, Ottawa, ON, K1H 8M5, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Divisions of Neuroscience and Neurology, The Ottawa Hospital Research Institute, University of Ottawa, 451 Smyth Road, RGH #1412, Ottawa, ON, K1H 8M5</wicri:regionArea><wicri:noRegion>K1H 8M5</wicri:noRegion></affiliation></author><author><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Neurology, Innsbruck Medical University, Anichstraße 35, Innsbruck 6020, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Innsbruck Medical University, Anichstraße 35, Innsbruck 6020</wicri:regionArea><wicri:noRegion>Innsbruck 6020</wicri:noRegion><placeName><settlement type="city">Innsbruck</settlement><region nuts="2" type="region">Tyrol (Land)</region></placeName><orgName type="university">Université de médecine d'Innsbruck</orgName></affiliation></author><author><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Neurology, Innsbruck Medical University, Anichstraße 35, Innsbruck 6020, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Innsbruck Medical University, Anichstraße 35, Innsbruck 6020</wicri:regionArea><wicri:noRegion>Innsbruck 6020</wicri:noRegion></affiliation></author></analytic><series><title level="j">Progress in Neurobiology</title><idno type="ISSN">0301-0082</idno><idno type="eISSN">1873-5118</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple"><list-item id="lsti0005"><label>•</label><p>This review summarizes the progress made in MSA research during the past decade.</p></list-item><list-item id="lsti0010"><label>•</label><p>Pre-motor features have gained relevance as early diagnostic markers.</p></list-item><list-item id="lsti0015"><label>•</label><p>Animal models have been exploited to discover novel interventional targets.</p></list-item><list-item id="lsti0020"><label>•</label><p>Candidate α-synuclein lowering therapies have been explored in preclinical models.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abe, H" uniqKey="Abe H">H. 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Yazawa</name></author><author><name sortKey="Giasson, B I" uniqKey="Giasson B">B.I. Giasson</name></author><author><name sortKey="Sasaki, R" uniqKey="Sasaki R">R. Sasaki</name></author><author><name sortKey="Zhang, B" uniqKey="Zhang B">B. Zhang</name></author><author><name sortKey="Joyce, S" uniqKey="Joyce S">S. Joyce</name></author><author><name sortKey="Uryu, K" uniqKey="Uryu K">K. Uryu</name></author><author><name sortKey="Trojanowski, J Q" uniqKey="Trojanowski J">J.Q. Trojanowski</name></author><author><name sortKey="Lee, V M" uniqKey="Lee V">V.M. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zuscik, M J" uniqKey="Zuscik M">M.J. Zuscik</name></author><author><name sortKey="Sands, S" uniqKey="Sands S">S. Sands</name></author><author><name sortKey="Ross, S A" uniqKey="Ross S">S.A. Ross</name></author><author><name sortKey="Waugh, D J" uniqKey="Waugh D">D.J. Waugh</name></author><author><name sortKey="Gaivin, R J" uniqKey="Gaivin R">R.J. Gaivin</name></author><author><name sortKey="Morilak, D" uniqKey="Morilak D">D. Morilak</name></author><author><name sortKey="Perez, D M" uniqKey="Perez D">D.M. Perez</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Autriche</li><li>Canada</li></country><region><li>Tyrol (Land)</li><li>Vienne (Autriche)</li></region><settlement><li>Innsbruck</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Kuzdas Wood, Daniela" sort="Kuzdas Wood, Daniela" uniqKey="Kuzdas Wood D" first="Daniela" last="Kuzdas-Wood">Daniela Kuzdas-Wood</name></noRegion><name sortKey="Jellinger, Kurt A" sort="Jellinger, Kurt A" uniqKey="Jellinger K" first="Kurt A." last="Jellinger">Kurt A. Jellinger</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Stefanova, Nadia" sort="Stefanova, Nadia" uniqKey="Stefanova N" first="Nadia" last="Stefanova">Nadia Stefanova</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country><country name="Canada"><noRegion><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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